Sunday, September 21, 2014

Quorum disruption

A recent paper in Chemistry and Biology describes how certain bacteria use small molecules to “quorum sense,” essentially coordinating an attack on the host. The study also demonstrates how minor tweaks in the concentration of these chemicals could substantially disrupt the “attack signal” that improves the efficiency of the pathogenic bacteria. In the era of declining effectiveness of antibacterial agents, this seems like a favorable direction for research.

Prevalent lack of innovation across the life sciences industry has kept a lid on tangible improvements in the quality of life for humans. Most of the current knowledge on how to attack pathogens has been stale for many decades. In a predictable fashion, the industry has turned into creating bigger “hammers” and if size does not do it, a cocktail of antibacterial agents to quell the infection. This brute force approach has led to the less intelligent micro-organism to simply fall back on mutations to get over what has been put in front of them, incrementally. There is no doubt who will win this war as bacteria has over 3 billion years of experience – and they are fully capable of upsetting incremental approaches to battle it.

Humans, arguably proud of the massive organ they carry on their shoulders, may have to get more sophisticated to stay ahead – taking yesterday’s technology and making it bigger is not going to do it. Disrupting communication signals seems like a better approach.